ZK824859 hydrochloride is an oral available and selective urokinase plasminogen activator ( uPA ) inhibitor with IC 50 s of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively. IC50& Target:IC50: 79 nM (human uPA), 1580 nM (human tPA), 1330 nM (human plasmin) . In Vitro:ZK824859 is 5 fold less potent and has lost selectivity in mouse: uPA IC 50 =410 nM; tPA IC 50 =910 nM; plasmin IC 50 =1600 nM compared to human IC 50 values of 79 nM, 1580 nM and 1330 nM respectively. MCE has not independently confirmed the accuracy In Vivo:ZK824859 (50, 25 and 10mg/kg; b.i.d.; 25 days) is used in a chronic mouse EAE model. ZK 824859 completely prevents the development of disease. However, two lower doses (25 and 10mg/kg) have no effect on clinical scores. MCE has not independently co Biological Activity:ZK824859 hydrochloride is an oral available and selective urokinase plasminogen activator ( uPA ) inhibitor with IC 50 s of 79u202fnM, 1580u202fnM and 1330u202fnM for human uPA, tPA, and plasmin, respectively.
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ZK824859 hydrochloride
CAS number：unknown molecular formula：C23H23ClF2N2O4
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| Chinese alias | ZK824859 盐酸盐 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C23H23ClF2N2O4 |
| molecular weight | 464.89 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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