β-CGRP, humanTFA是一种降钙素肽，通过降钙素受体样受体CRLR与RAMP的复合物起作用，在细胞体系中，对CRLR/RAMP1和CRLR/RAMP2的IC50值分别为1nM和300nM。 序列： Ala-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Met-Val-Lys-Ser-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH2(Disulfide bridge: Cys2-Cys7) 简短序列： ACNTATCVTHRLAGLLSRSGGMVKSNFVPTNVGSKAF-NH2(Disulfide bridge: Cys2-Cys7) β-CGRP, human TFA (Human β-CGRP TFA) is one of calcitonin peptides , acts via the complex of calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP), with IC 50 s of 1 nM and 300 nM for CRLR/RAMP1 and CRLR/RAMP2 in cells. Appearance:Solid IC50& Target:IC50: 1 nM (CRLR/RAMP1, cell assay), 300 nM (CRLR/RAMP2, cell assay) In Vitro:β-CGRP, human is one of calcitonin peptides, acts via complex of calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP), with IC 50 s of 1 nM in both SK-N-MC and Swiss 3T3 cells express CRLR and RAMP1, and 130 nM and 300 n Biological Activity:β-CGRP, human TFA (Human β-CGRP TFA) is one of calcitonin peptides , acts via the complex of calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP), with IC 50 s of 1 nM and 300 nM for CRLR/RAMP1 and CRLR/RAMP2 in cells.
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β-CGRP, human TFA
CAS number：101462-82-2(free base) molecular formula：C162H267N51O48S3.xC2HF3O2
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Specs
| Chinese alias | - | ||
| English alias | Human β-CGRP TFA | CGRP-II (Human) TFA | ||
| CAS number | 101462-82-2(free base) | molecular formula | C162H267N51O48S3.xC2HF3O2 |
| molecular weight | 3793.41 (free base) | Exact mass | ≥98% |
| PSA | - | logp | - |
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