D-Cl-amidine hydrochloride is a potent and highly selective PAD1 inhibitor. D-Cl-amidine is well-torelated with no significant toxicity. Appearance:Solid In Vitro:D-Cl-amidine (200-400 μM) is effective in significantly decreasing cell viability in MDA-MB-231 cells. D-Cl-amidine increase caspase 3 activity, indicating that inhibition of PAD1 leads to an increase in apoptosis. MCE has not independently conf In Vivo:D-Cl-amidine, administered by iv at a dose of 2.5mg/kg, is still detected after 2 h in serum at a concentration of ~21 nM and at 4 h at ~10 nM. D-Cl-amidine is still observed in the blood serum at a concentration of ∼10 nM at 4 h when administered by ip Biological Activity:D-Cl-amidine hydrochloride is a potent and highly selective PAD1 inhibitor. D-Cl-amidine is well-torelated with no significant toxicity.
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D-Cl-amidine hydrochloride
CAS number：unknown molecular formula：C14H20Cl2N4O2
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| Chinese alias | D-Cl-脒盐酸盐 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C14H20Cl2N4O2 |
| molecular weight | 347.24 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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