compound introduction
WAY-213613 是一个有效，选择性的，非底物再摄取 GLT-1/EAAT2 抑制剂，对 EAAT2 的 IC50 为 85 nM。WAY-213613 对 EAAT1 和 EAAT3 的选择性是 59 倍和 44 倍 (IC50 分别为 5 和 3.8 μM)。WAY-213613 对离子型和代谢型谷氨酸受体无活性。它是阐明 EAAT2 功能的潜在工具。
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WAY-213613 hydrochloride
CAS number：2450268-84-3 molecular formula：C16H13BrF2N2O4(free base)
overview
Specs
| Chinese alias | N-[4-(2-溴-4,5-二氟苯氧基)苯基] -L-天冬酰胺盐酸盐 | WAY-213613 盐酸盐 | ||
| English alias | N-[4-(2-Bromo-4,5-difluorophenoxy)phenyl]-L-asparagine | WAY-213613 | (S)-2-amino-4-((4-(2-bromo-4,5-difluorophenoxy)phenyl)amino)-4-oxobutanoic acid | ||
| CAS number | 2450268-84-3 | molecular formula | C16H13BrF2N2O4(free base) |
| molecular weight | 415.19(free base) g/ | Exact mass | ≥98% |
| PSA | - | logp | - |
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