(S)-Carvedilol, the S-enantiomer of Carvedilol, is a non-selective β/α-1 blocker. (S)-Carvedilol exerts protection against the vascular or cardiac toxicity of Doxorubicin (DOX) In Vitro The β-receptor blocking activity of (S)-Carvedilol is about 100 times greater than that of (R)-Carvedilol, whereas both enantiomers show equipotent potency as α-blockers. (S)-Carvedilol significantly attenuates Doxorubicin (DOX)-induced cell death, apoptotic morphological changes, decrease the mitochondrial membrane potential and oxidative stress responses by increasing the superoxide dismutase and catalase activities, and decreasing malondialdehyde contents and reactive oxygen species levels via the PI3K/AKT/eNO synthase pathway in vitro. (S)-Carvedilol treatment significantly upregulates the expression levels of p-eNOS in HUVECs. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:β/α-1 adrenergic receptor
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(S)-Carvedilol
CAS number：95094-00-1(DMSO) molecular formula：C24H26N2O4
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| Chinese alias | (S)-卡维地洛 | ||
| English alias | - | ||
| CAS number | 95094-00-1(DMSO) | molecular formula | C24H26N2O4 |
| molecular weight | 406.47 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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