KP496 is a selective, dual antagonist for Leukotriene D4 receptor and Thromboxane A2 receptor . In Vivo KP496 significantly inhibits acute (day 7) and chronic (day 21) lung inflammation. KP496 attenuates the number of lymphocytes on day 7 and those of macrophages, neutrophils, and eosinophils on days 7 and 21. KP496 and prednisolone significantly suppress the increase of hydroxyl-L-proline content in the lung. Compare to respective vehicle control group, the inhibition ratio of KP496 and prednisolone for increase of hydroxyl-L-proline content is about 74 and 63%, respectively . The KP496 (100 mg/head) group and prednisolone (10 mg/kg) group exhibit significant inhibition of numbers of infiltrating total cells, eosinophils, monocytes/macrophages, and lymphocytes compare with the control group. Infiltration of all types of cells except neutrophils is decreased in the KP496 (30m g/head) group, though not to significant extents. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:LTD 4 TXA 2 Receptor
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KP496
CAS number：217799-03-6 molecular formula：C31H34ClN3O7S3
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| Chinese alias | - | ||
| English alias | KP496 | KP-496 | 2-[4-[(4-chlorophenyl)sulfonylamino]butyl-[[3-[(4-propan-2-yl-1,3-thiazol-2-yl)methoxy]phenyl]methyl]sulfamoyl]benzoic acid | AKOS040733535 | QQB95VUD4B | UNII-QQB95VUD4B | 2-(4-((4-Chlorophenyl)sulfonylamino)butyl-((3-((4-isopropylthiazo | ||
| CAS number | 217799-03-6 | molecular formula | C31H34ClN3O7S3 |
| molecular weight | 692.27 g/mol | Exact mass | ≥99% |
| PSA | 188.000 Ų | logp | 5.800 |
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