Amorfrutin A

它是一种源自植物来源的天然产物，可用于化合物筛选文库，代谢组学，植物化学和药物研究。 Amorfrutin A是一种类异戊二烯取代的苯甲酸天然产物，存在于A.fruticosa和G.foetida的果实中，具有抗糖尿病作用。它以0.236µM的Ki与PPARγ结合，并激活PPARγ基因报告基因检测，EC50值为0.458µM.1。在高脂饮食诱导的肥胖（DIO）小鼠中，阿莫呋汀a（100 mg/kg/天）增强了葡萄糖耐量和胰岛素敏感性，同时降低了血浆甘油三酯，游离脂肪酸，胰岛素和葡萄糖浓度。阿莫呋汀a通过抑制NF-κ抑制TNF-α诱导的许多炎症基因的表达，例如COX-2，IL-1β，MCP-1，MIP-2，MIP-3α，MMP-9和IL-8 B和PPARγ活性，效力为5-20μM。 根据现有研究，阿莫呋汀-A证明了其抑制NF-κB活性的能力，NF-κB活性是控制多种细胞功能（如免疫反应，细胞凋亡，肿瘤生长和组织发育）的基因的关键调节因子。此外，它通过与核受体PPARγ相互作用在结肠细胞中表现出抗炎特性，导致炎症介质的表达和分泌减少。这表明它有治疗炎症性肠病等疾病的潜力。此外，它还通过结合并激活核受体PPARγ表现出抗糖尿病活性。 适合多种研究应用的高质量化合物与HPLC和质谱技术兼容。 It is a natural product derived from plant source that finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research. Amorfrutin A is an isoprenoid-substituted benzoic acid natural product found in the fruit of A. fruticosa and G. foetida that exhibits antidiabetic effects. It binds to PPARγ with a Ki of 0.236 µM and activates a PPARγ gene reporter assay with an EC50 value of 0.458 µM.1 In high-fat diet-induced obese (DIO) mice, amorfrutin A (100 mg/kg/day) enhanced glucose tolerance and insulin sensitivity, while decreasing plasma triglycerides, free fatty acids, insulin, and glucose concentrations.1 Amorfrutin A inhibits TNF-α-induced expression of a number of inflammatory genes such as COX-2, IL-1β, MCP-1, MIP-2, MIP-3α, MMP-9, and IL-8 through inhibition of both NF-κB and PPARγ activity with efficacy at 5-20 µM. According to the existing research, Amorfrutin-A demonstrated its ability to inhibit NF-κB activity, a pivotal regulator of genes governing a wide range of cellular functions, such as immune responses, apoptosis, tumor growth, and tissue development. Furthermore, it exhibits anti-inflammatory properties in colon cells by interacting with the nuclear receptor PPARγ, resulting in the reduced expression and secretion of inflammatory mediators. This suggests its potential for treating conditions like inflammatory bowel diseases. Additionally, it also exhibited antidiabetic activity through binding to and activating the nuclear receptor PPARγ. High quality compound suitable for multiple research applications；Compatible with HPLC and mass spectrometry techniques.

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