PBOX 6 is a pyrrolo-1,5-benzoxazepine (PBOX) compound, acts as a microtubule -depolymerizing agent and an apoptotic agent. In Vitro PBOX 6 is a potent apoptotic PBOX, but does not elicit a general toxic effect in a rat R2C Leydig cell line. PBOX 6 (0-25 μM, 16 h) results in dose- and time-dependent induction of apoptosis, and also causes DNA fragmentation at 10 μM in HL-60 cells. PBOX 6 (10 μM) induces apoptosis through activation of caspase 3-like proteases in HL-60 cells. PBOX 6 (10 μM) induces apoptosis and exerts an accumulation of cytochromec in the cytosol, but this effect is not triggered by oxidative stress, and is independent of peripheral-type benzodiazepine receptor (PBR) and NF-κB. PBOX 6 (25 μM) induces apoptosis in MCF-7 cells through activation of caspase-7. PBOX 6 (10 μM) induces the redistribution of cypA from the nucleus to the cytosol of the cell in K562 cells. PBOX 6 (10 μM) induces nucleocytoplasmic redistribution of cypA and pin1 through a JNK-dependent manner, also dependent on upstream activation of a trypsin-like serine protease, and this effect correlates with G2/M arrest in K562 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Apoptosis, Microtubule
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PBOX 6
CAS number：290814-68-5 molecular formula：C25H20N2O3
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| Chinese alias | - | ||
| English alias | PBOX-6 | 7-[(N,N-dimethylcarbamoyl)oxy]-6-(naphth-1-yl)pyrrolo[2,1-d][1,5]benzoxazepine | MS-26682 | HY-U00446 | Carbamic acid, N,N-dimethyl-, 6-(1-naphthalenyl)pyrrolo(2,1-d)(1,5)benzoxazepin-7-yl ester | AKOS040742367 | PBOX 6 | pyrrolo-1,5-benzoxazepin | ||
| CAS number | 290814-68-5 | molecular formula | C25H20N2O3 |
| molecular weight | 396.44 g/mol | Exact mass | ≥99% |
| PSA | 43.700 Ų | logp | 4.800 |
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