Maytansine is a highly potent microtubule-targeted compound that induces mitotic arrest and kills tumor cells at subnanomolar concentrations. In Vitro Maytansine, at 6x10 -8 M, irreversibly inhibits cell division in eggs of sea urchins and clams. Maytansine causes the disappearance of a mitotic apparatus or prevents one from forming if added at early stages. Maytansine inhibits in vitro polymerization of tubulin. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid
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Maytansine
CAS number:35846-53-8 molecular formula:C34H46ClN3O10
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Specs
| Chinese alias | 美登素 | 美坦新 | (14S,16S,32S,33S,2R,4S,10E,12E,14R)-86-氯-14-羟基-85,14-二甲氧基-33,2,7,10-四甲基-12,6-二氧代-7-氮杂-1(6,4)-恶嗪-3(2,3)-环氧乙烷-8(1,3)-苯并环十四烷-10,12-二烯-4-基 N-乙酰基-N-甲基-L-丙氨酸盐 | ||
| English alias | Maitansine | Maytansin | NSC 153858 | MTS | N-Acetyl-N-methyl-L-alanine [1S-(1R*,2S*,3R*,5R*,6R*,16E,18E,20S*,21R*)]-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14( | ||
| CAS number | 35846-53-8 | molecular formula | C34H46ClN3O10 |
| molecular weight | 692.2 g/mol | Exact mass | - |
| PSA | 156.000 Ų | logp | 2.000 |
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