Pelecopan (BCX9930) is a potent, selective, orally active inhibitor of complement factor D with an IC 50 value of 14.3 nM. Pelecopan can target factor D to prevent both intravascular and extravascular hemolysis in PNH. Pelecopan also be used for other alternative pathway (AP) mediated diseases In Vitro Pelecopan has a potent, highly specific inhibitory activity for purified human factor D with an IC 50 value of 14.3 nM and also inhibits its proteolytic activity against factor B bound to C3b with an IC 50 of 28.1 nM. Pelecopan completely blocks hemolysis of PNH cells in vitro (with an IC 50 value of 29.5 nM in rabbit erythrocytes) and suppresses the accumulation of C3 fragments on PNH erythrocytes. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 14.3 nM (complement factor D)
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Pelecopan
CAS number：2378380-49-3 molecular formula：C23H19FN2O4
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| Chinese alias | 佩莱科潘 | ||
| English alias | - | ||
| CAS number | 2378380-49-3 | molecular formula | C23H19FN2O4 |
| molecular weight | 406.41 g/mol | Exact mass | ≥97% |
| PSA | - | logp | - |
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