GA-017 is a potent and selective LATS1 and LATS2 (large tumor suppressor kinase 1/2) inhibitor, with IC 50 values of 4.10 and 3.92 nM, respectively. GA-017 is an activator of cell proliferation. GA-017 promotes YAP/TAZ activation and nuclear translocation. GA-017 promotes cell growth under 3D culture conditions. GA-017 enhances the ex vivo formation of mouse intestinal organoids In Vitro GA-017 suppresses the cell death of HUVECs and promotes their cell growth. GA-017 facilitates SKOV3 cell growth, with an EC 50 of 3.51 ± 0.26 μM. GA-017 competitively inhibited LATS1 and 2 against ATP, with K i (inhibition constant) values of 0.58 ± 0.11 and 0.25 ± 0.03 nM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC 50 : 3.92 ± 0.42 nM (LATS2), 4.10 ± 0.79 nM (LATS1)
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GA-017
CAS number：2351906-74-4(DMSO) molecular formula：C18H21N3O4
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 2351906-74-4(DMSO) | molecular formula | C18H21N3O4 |
| molecular weight | 343.38 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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