YAP/TAZ inhibitor-2 is a potent and orally active TEAD-YAP/TAZ inhibitor with an EC 50 value of 3 nM. YAP/TAZ inhibitor-2 shows anti-proliferative activity. YAP/TAZ inhibitor-2 shows antitumor activity In Vitro YAP/TAZ inhibitor-2 (compound 5) (0-20000 nM; 24 h) shows antiproliferative activity with an IC 50 value of 5.33 nM in NCI-H226 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo YAP/TAZ inhibitor-2 (0.5, 2, 5, 50 mg/kg; p.o.; daily for 28 days) shows anti-tumor activity with no significant body weight loss during the treatment in BALB/c nude mice (NCI-H226 xenograft model) . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:EC 50 : 3 nM (TEAD-YAP/TAZ)
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YAP/TAZ inhibitor-2
CAS number：2762617-31-0 molecular formula：C19H14F4N4O
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| Chinese alias | YAP/TAZ 抑制剂-2 | ||
| English alias | - | ||
| CAS number | 2762617-31-0 | molecular formula | C19H14F4N4O |
| molecular weight | 390.33 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
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