Rineterkib hydrochloride (compound B) is an orally available ERK1 and ERK2 inhibitor in the treatment of a proliferative disease characterized by activating mutations in the MAPK pathway. The activity is particularly related to the treatment of KRAS-mutant NSCLC, BRAF-mutant NSCLC, KRAS-mutant pancreatic cancer , KRAS-mutant colorectal cancer (CRC) and KRAS-mutant ovarian cancer. Rineterkib hydrochloride can also inhibit RAF. In Vivo ERK-IN-1 (compound B) (50, 75 mg/kg, p.o., qd/q2d, 27 days) treatment significantly reduces the tumor volume in the Calu-6 human NSCLC subcutaneous tumor xenograft model in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Calu-6 NSCLC xenograft tumor models in mice . Dosage: 50, 75 mg/kg. Administration: Orally either daily (qd) or every other day (q2d) for 27 days. Result: Significantly reduced the tumor volume. Form:Solid
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Rineterkib hydrochloride
CAS number：1715025-34-5 molecular formula：C26H28BrClF3N5O2
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| Chinese alias | 盐酸利奈替克 | ||
| English alias | Rineterkib hydrochloride | 4-[3-amino-6-[(1S,3S,4S)-3-fluoro-4-hydroxycyclohexyl]pyrazin-2-yl]-N-[(1S)-1-(3-bromo-5-fluorophenyl)-2-(methylamino)ethyl]-2-fluorobenzamide;hydrochloride | 1715025-34-5 | Benzamide, 4-(3-amino-6-((1S,3S,4S)-3-fluoro-4-hydroxy | ||
| CAS number | 1715025-34-5 | molecular formula | C26H28BrClF3N5O2 |
| molecular weight | - | Exact mass | ≥99% |
| PSA | - | logp | - |
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