Rp-cAMPS sodium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II ( K i s of 12.5 µM and 4.5 µM, respectively) antagonist. Rp-cAMPS sodium salt is resistant to hydrolysis by phosphodiesterases In Vitro A membrane-permeable competitive cAMP antagonist (Rp-cAMPS) that blocks PKA activation by binding to the regulatory subunits without dissociating the kinase holoenzyme also inhibits synaptic plasticity but has no effect on normal synaptic transmission. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Rp-cAMPS (10 μM, 15 min) decreases the monosynaptic EPSCs evoked at the PB-CeLC and BLA-CeLC synapses in slices from arthritic rats but not in control neurons from normal animals. The inhibitory effect of Rp-cAMPS is significant compared to predrug (ACSF) control values obtained in the same neurons. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Ki: 6.05 µM (PKA I) and 9.75 µM (PKA II)
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Rp-cAMPS sodium salt
CAS number：142439-94-9 molecular formula：C10H11N5NaO5PS
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| Chinese alias | Rp-cAMPS钠盐 | ||
| English alias | - | ||
| CAS number | 142439-94-9 | molecular formula | C10H11N5NaO5PS |
| molecular weight | 367.25 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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