SRI-011381 hydrochloride is an orally active TGF-β signaling agonist, exhibits neuroprotective effects In Vitro SRI-011381 (10 μM) hydrochloride promotes the proliferation of mouse lung fibroblasts, and significantly increases TGF-β1, NALP3, collagen-1, and α-SMA expression. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo SRI-011381 (30 mg/kg; i.p.; every 2 d; for 22 days) hydrochloride partially rescues the deficits in optic nerve and retina of YAPGFAP-CKO EAE mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: YAPGFAP-CKO mice bearing experimental autoimmune encephalomyelitis (EAE)Dosage: 30 mg/kg Administration: Intraperitoneally injection; every 2 d; for 22 days Result: Significantly inhibited inflammatory infiltration and relieved the loss of neurons in YAPGFAP-CKO EAE mice. Form:Solid IC50& Target:TGF-beta
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SRI-011381 hydrochloride
CAS number：2070014-88-7 molecular formula：C20H32ClN3O
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| Chinese alias | SRI-011381 盐酸盐 | ||
| English alias | - | ||
| CAS number | 2070014-88-7 | molecular formula | C20H32ClN3O |
| molecular weight | 365.94 g/mol | Exact mass | ≥99% |
| PSA | 44.400 Ų | logp | - |
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