Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) TFA is a potent peptide antagonist of FZD7 receptors , selectively binds to FZD7 CRD subclass and alters the conformation of the CRD and the architecture of its lipid-binding groove. The EC 50 values are 58 and 34 nM for hum Appearance:Solid IC50& Target:EC50: 58 nM (human FZD7 CRD), 34 nM (mouse FZD7 CRD) In Vitro:Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) TFA (0-100 μM; 6 h; HEK293-TB cells) impairs Wnt signaling with IC 50 value of 100 nM. Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) TFA (1 µM) blocks WNT3A-mediated stabilization of β-catenin in mouse L cells with IC 50 value of 50 n Biological Activity:Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) TFA is a potent peptide antagonist of FZD7 receptors , selectively binds to FZD7 CRD subclass and alters the conformation of the CRD and the architecture of its lipid-binding groove. The EC 50 values are 58 and 34 nM for hum
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Fz7-21 TFA
CAS number：unknown molecular formula：C85H115N18F3O25S2
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| Chinese alias | Fz7-21三氟乙酸 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C85H115N18F3O25S2 |
| molecular weight | 1910.07 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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