7,4'-Dihydroxyflavone 是 eotaxin/CCL11 和 CBR1 抑制剂 (IC50=0.28 μM)，抑制嗜酸性粒细胞趋化因子产生。7,4'-Dihydroxyflavone 通过调节 NF-κB，STAT6 和 HDAC2 抑制 MUC5A 基因表达和粘液产生。7,4'-Dihydroxyflavone 降低 (PMA) 刺激的 NCI-H292 细胞 MUC5AC 表达，IC50 值为 1.4 μM。 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor (IC50=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production[1]. 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC50 value of 1.4 µM.
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7,4'-Dihydroxyflavone
CAS number：2196-14-7 molecular formula：C15H10O4
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Specs
| Chinese alias | 7,4'-二羟基黄酮 | ||
| English alias | SR-05000002501-1 | 7, 4'-Dihydroxyflavone | MS-23576 | SPECTRUM1500721 | UNII-53ZZF57X0U | 7-hydroxy-2-(4-hydroxyphenyl)chromen-4-one | LMPK12110035 | 4',7-Dihydroxyflavone | SCHEMBL157723 | CCG-231475 | 7-Hydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one # | | ||
| CAS number | 2196-14-7 | molecular formula | C15H10O4 |
| molecular weight | 254.24 g/mol | Exact mass | - |
| PSA | 66.800 Ų | logp | 3.300 |
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