P11149 is a competitive, BBB-penetarated weakly, orally active and selective inhibitor of AChE . P11149 exhibits an IC 50 of 1.3 μM for rat BChE/AChE. P11149, a Galanthamine derivative, demonstrates central cholinergic activity, behavioral efficacy and safety. P11149 is used in the study for Alzheimer's disease In Vivo P11149 is a GAL analog that is rapidly hydrolyzed in vivo to yield the potent AChE inhibitor, 6-DMG . P11149 exhibits greater s.c. bioavailability than p.o. . Oral P11149 in mice produces Sal, Lac and tremors at doses similar to those in rats, whereas 6-DMG, P1 1012 and GAL produces Sal and Lac at doses lower than those in rats . P11149 exhibits T 1/2 (el) of 2.4 h and C max of 585 ng/mL in rat plasma . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 1.3 μM (rat BChE/AChE)
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P11149
CAS number：164724-79-2 molecular formula：C27H34ClNO4
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 164724-79-2 | molecular formula | C27H34ClNO4 |
| molecular weight | 472.02 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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