TP-020 (MGAT2-IN-1) is an orally active inhibitor of monoacylglycerol acyltransferase (MGAT2) with IC 50 of 7.8 and 2.4 nM for human and mouse MGAT2 , respectively. In Vivo TP-020 (3, 10 mg/kg, p.o.) dose-dependently suppresses plasma TG elevation, and plasma CM/TG AUC in mice. TP-020 does not decrease MG absorption but inhibits MGAT2-dependent TG/DG resynthesis. In the lipid utilization analysis, TP-020 significantly increases free fatty acid (FFA) and acylcarnitine levels. TP-020 (30 mg/kg) also significantly reduces food intake dose dependently, suppresses BW gains. TP-020 shows anti-diabetic effects in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC50: 7.8 nM (Human MGAT2), 2.4 nM (Mouse MGAT2)
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TP-020
CAS number：1800025-30-2(DMSO) molecular formula：C27H21ClF5N7O3S
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 1800025-30-2(DMSO) | molecular formula | C27H21ClF5N7O3S |
| molecular weight | 654.01 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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