JNJ-54175446 is a potent and selective brain penetrant P2X7 receptor antagonist, with pIC 50 s of 8.46 and 8.81 for hP2X7 receptor and rP2X7 receptor, respectively. In Vitro JNJ-54175446 (Compound 14) is a potent and selective brain penetrant P2X7 antagonist, with pIC 50 s of 8.46 and 8.81 for hP2X7 and rP2X7, respectively. JNJ-54175446 shows less potent activity against mouse, dog and Macaque P2X7 (pIC 50 , 7.8, 7.9 and 8.1, respectively). MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo JNJ-54175446 shows dose-dependent occupancy with the ED 50 of 0.46 mg/kg, corresponding to plasma EC 50 of 105 ng/mL . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:pIC50: 8.46 (hP2X7 receptor), 8.81 (rP2X7 receptor)
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JNJ-54175446
CAS number：1627902-21-9 molecular formula：C18H13ClF4N6O
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| Chinese alias | - | ||
| English alias | BDBM254266 | TQR1090 | AS-35269 | MFCD31556312 | US9464084, 158 | [2-chloro-3-(trifluoromethyl)phenyl]-[(4R)-1-(5-fluoropyrimidin-2-yl)-4-methyl-6,7-dihydro-4H-triazolo[4,5-c]pyridin-5-yl]methanone | (R)-(2-chloro-3-(trifluoromethyl)phenyl)(1-(5-fluoropyr | ||
| CAS number | 1627902-21-9 | molecular formula | C18H13ClF4N6O |
| molecular weight | 440.78 g/mol | Exact mass | ≥99% |
| PSA | 76.800 Ų | logp | 3 |
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