compound introduction
Indimitecan (LMP776) is a topoisomerase I ( Top1 ) inhibitor with anticancer activities In Vitro Indimitecan (LMP776) (0-100 μM) shows antiproliferative potencies against various human cancer cell lines, with mean-graph midpoint (MGM) of 0.079 ± 0.023 μM. Indimitecan shows potent DNA cleavage due to Top1 inhibition. Indimitecan can be substrates for metabolic ketone reductases. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: HOP-62, HCT-116, SF-539, UACC-62, OVCAR-3, SN12C, DU-145, MCF-7 Concentration: 0-100 μM Incubation Time: Result: Showed growth inhibition with GI 50 s of Form:Solid IC50& Target:Top1
