FTY720 (S)-Phosphate is an agonist of S1P receptor 1 (S1PR1) , used in the research of acute inflammatory diseases such as acute lung injury. In Vitro FTY720 (S)-Phosphate is an agonist of S1PR1. FTY720 (S)-Phosphate (Tys, 1 μM) maintains S1PR1 protein expression, enhances the human pulmonary artery endothelial cells barrier via S1PR1, but shows no effect on inducing ubiquitination of S1PR1. FTY720 (S)-Phosphate (0.01-50 μM) also reduces β-arrestin recruitment to S1PR1. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo FTY720 (S)-Phosphate (0.5 mg/kg, i.p.) preserves S1PR1 expression in mouse lungs, is protective in bleomycin-induced acute lung injury (ALI) and attenuates lung tissue leukocyte infiltration in bleomycin-injured mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:S1PR1
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(S)-FTY720-phosphonate
CAS number：1142015-10-8 molecular formula：C20H36NO4P
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| Chinese alias | (S)-FTY720-膦酸酯 | ||
| English alias | - | ||
| CAS number | 1142015-10-8 | molecular formula | C20H36NO4P |
| molecular weight | 385.48 g/mol | Exact mass | - |
| PSA | - | logp | - |
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