ADRA1D receptor antagonist 1 is a potent, selective and orally active α 1D adrenoceptor antagonist, with a K i of 1.6 nM In Vitro ADRA1D receptor antagonist 1 shows low hERG inhibition. ADRA1D receptor antagonist 1 exhibits higher selectivity for α1D-AR over α1A- and α1B-ARs. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo ADRA1D receptor antagonist 1 (4.4 µg/kg; i.v.) dose-dependently decreases the non-voiding bladder contractions during the urinary storage phase in rats with BOO . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Rat with bladder outlet obstruction (BOO) Dosage: 4.4 µg/kg Administration: Intravenous injection Result: Dose-dependently decreased the non-voiding bladder contractions during urinary storage phase in rats with BOO. IC50& Target:Ki: 1.6 nM (α 1D adrenoceptor)
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
ADRA1D receptor antagonist 1
CAS number：1191908-14-1(DMSO) molecular formula：C15H14Cl2N4O
overview
compound introduction
Specs
| Chinese alias | ADRA1D 受体拮抗剂 1 | ||
| English alias | - | ||
| CAS number | 1191908-14-1(DMSO) | molecular formula | C15H14Cl2N4O |
| molecular weight | 337.20 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
No safety information yet
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
