compound introduction
SIRT-IN-1 is a potent inhibitor of SIRT1/2/3 , with IC 50 s of 15, 10, 33 μM, respectively. In Vitro SIRT-IN-1 (compound 28) is one of the most potent truncated pan SIRT1/ 2/3 inhibitor, the IC 50 values are 0.015, 0.010, 0.033 μM, respectively. SIRT-IN-1 (SIRT1/2/3 pan inhibitor) binds identically in the catalytic active site (RMS=0.29 Å), occupying the nicotinamide C-pocket and acetyl lysine substrate channel. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:SIRT1 15 nM (IC 50 ) SIRT2 10 nM (IC 50 ) SIRT3 33 nM (IC 50 )
