APX-115 (Ewha-18278) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with K i values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1 , Nox2 and Nox4 , respectively. APX-115 effectively prevents kidney injury In Vitro APX-115 (5?μM; 60?min) almost completely suppresses high glucose-induced proinflammatory and profibrotic molecule expression in the mouse podocyte cell line. ? In the kidney, APX-115 attenuates Nox gene upregulation and protein expression while improving inflammatory and fibrotic processes. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo APX-115 (oral gavage; 60?mg/kg/day; for 12 weeks) significantly improves insulin resistance in diabetic mice. ? APX-115 treatment decreases the urinary excretion of albumin and plasma creatinine levels. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Six-week-old male diabetic db/db mice (C57BLKS/J- lepr db /lepr db )Dosage: 60 mg/kg Administration: Oral gavage; per day; for 12 weeks Result: Significantly improved insulin resistance in diabetic mice. Form:Solid IC50& Target:NOX1 NOX2 NOX4
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
APX-115
CAS number：1395946-75-4 molecular formula：C17H18ClN3O
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | 1H-Pyrazol-5-ol, 3-phenyl-4-propyl-1-(2-pyridinyl)-, hydrochloride (1:1) | HY-120801 | 1395946-75-4 | Apx 115 | Q99G5ZE5U5 | APX 115 [WHO-DD] | Isuzinaxib hydrochloride | SCHEMBL15610231 | UNII-Q99G5ZE5U5 | 5-phenyl-4-propyl-2-pyridin-2-yl-1H-pyrazol-3-on | ||
| CAS number | 1395946-75-4 | molecular formula | C17H18ClN3O |
| molecular weight | 315.80 g/mol | Exact mass | ≥99% |
| PSA | 45.200 Ų | logp | - |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
No safety information yet
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
