UK-371804 is a urokinase-type plasminogen activator ( uPA ) inhibitor with a K i of 10 nM. In Vitro UK-371804 is able to inhibit exogenous uPA in human chronic wound fluid (IC 50 =0.89 μM). UK-371804 has its excellent enzyme potency (K i =10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin). MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo In a porcine acute excisional wound model, following topical delivery, UK-371804 is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters. Concentrations of UK-371804 in the dermis are 41.8 μM . MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:Ki: 10 nM (uPA)
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
UK-371804
CAS number：256477-09-5(DMSO) molecular formula：C14H16ClN5O4S
overview
compound introduction
Specs
| Chinese alias | 英国-371804 | ||
| English alias | - | ||
| CAS number | 256477-09-5(DMSO) | molecular formula | C14H16ClN5O4S |
| molecular weight | 385.83 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
No safety information yet
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
