FSCPX is a potent and selective irreversible antagonist of A 1 adenosine receptor (A 1 AR) , with low nanomolar potency for binding to the A 1 AR. FSCPX could modify the effect of NBTI, a nucleoside transport inhibitor, by reducing the interstitial adenosine level in the guinea pig atrium In Vitro FSCPX irreversibly blocks the binding of [ 3 H]-8-cyclopentyl-1,3dipropylxanthine ([ 3 H]DPCPX), with an IC 50 of 11.8±3.2 nM in DDT 1 MF2 cells. FSCPX (20 μM; 48 h) attenuates protection from necrosis and apoptosis in A1AR-overexpressing LLC-PK1 cells. FSCPX (2-20 μM; 48 h) reverses the upregulation of HSP27 mRNA and protein in A1AR-overexpressing LLC-PK1 cells without an effect on the mRNA or protein for HSP70. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:A1AR
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FSCPX
CAS number：156547-56-7 molecular formula：C23H27FN4O6S
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| Chinese alias | - | ||
| English alias | J-009310 | CCG-204598 | 3-(8-Cyclopentyl-2,6-Dioxo-1-Propyl-7H-Purin-3-ylPropyl 4-Fluorosulfonylbenzoate | Lopac-F-7927 | SR-01000075884-1 | NCGC00093905-02 | BDBM50039676 | 8-Cyclopentyl-N3-[3-(4-(fluorosulfonyl)benzoyloxy)propyl]-N1-propylxanthine | HY- | ||
| CAS number | 156547-56-7 | molecular formula | C23H27FN4O6S |
| molecular weight | 506.55 g/mol | Exact mass | ≥99% |
| PSA | 138.000 Ų | logp | 5.100 |
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