compound introduction
10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) is a brain-targeting bioprecursor proagent of the main human estrogen , 17β-estradiol, alleviates hot flushes in rat models of thermoregulatory dysfunction of the brain. In Vivo 10β,17β-dihydroxyestra-1,4-dien-3-one (DHED), is an inactive bioprecursor prodrug of 17β-estradiol converting to 17β-estradiol only in the brain. DHED as an E2-bioprecursor may be a viable approach for delivering E2 selectively into the brain for the potential treatment of hot flushes . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
