NMI 8739 is a dopamine D 2 autoreceptor agonist, which is an amine conjugate of the DHA carrier and the neurotransmitter dopamine. In Vitro NMI 8739 is a dopamine D 2 autoreceptor agonist, which is an amine conjugate of the DHA carrier and the neurotransmitter dopamine. NMI 8739 reduces nitric oxide (NO) production in LPS-stimulated RAW264.7 Macrophages. NMI 8739 elicits concentration-dependent suppression of CCL-20, MCP-1 and IL-6 Release in RAW264.7 macrophages after LPS-stimulation. Production of PGE2 is concentration-dependently suppressed with a reduction of 25.3% at 100 nM NMI 8739 and a 75% reduction for 1 μM NMI 8739. 2 μM NMI 8739 significantly inhibits IL-6 and CCL-20 release up to 49% and 37%, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Oil
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NMI 8739
CAS number：129024-87-9 molecular formula：C30H41NO3
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| Chinese alias | - | ||
| English alias | NCGC00161234-02 | n-docosahexaenoyl dopamine | MS-28532 | Nmi-8739 | SCHEMBL11888439 | (4Z,7Z,10Z,13Z,16Z,19Z)-N-[2-(3,4-dihydroxyphenyl)ethyl]docosa-4,7,10,13,16,19-hexaenamide | AKOS040733009 | HY-101540 | 4,7,10,13,16,19-Docosahexaenoic acid dopamine c | ||
| CAS number | 129024-87-9 | molecular formula | C30H41NO3 |
| molecular weight | 463.65 g/mol | Exact mass | ≥99% |
| PSA | 69.600 Ų | logp | 5.700 |
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