Sigma‑1 receptor antagonist 1 (compound 137) is a potent and selective sigma-1 receptor (σ1R) antagonist, with a high binding affinity to σ1R receptor ( K i = 1.06 nM). Sigma‑1 receptor antagonist 1 exhibits antineuropathic pain activity and acts as a promising agent for the treatment of neuropathic pain In Vitro Sigma‑1 receptor antagonist 1 exhibits a high binding affinity to σ1R receptor (K i = 1.06 nM) and good σ-1/2 selectivity (1344-fold). MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Sigma‑1 receptor antagonist 1 exerts dose-dependent antinociceptive effects in mice formalin model and rats CCI models of neuropathic pain . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Sigma 1 Receptor
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Sigma-1 receptor antagonist 1
CAS number：1639220-19-1 molecular formula：C19H23Cl2N3O
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| Chinese alias | Sigma-1 受体拮抗剂 1 | ||
| English alias | - | ||
| CAS number | 1639220-19-1 | molecular formula | C19H23Cl2N3O |
| molecular weight | 380.31 g/mol | Exact mass | ≥99% |
| PSA | 38.300 Ų | logp | 5.100 |
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