与包含不同 PEG 链长的非均匀混合物的典型 PEG 试剂相比，该 PEG 试剂是具有确定的分子量和间隔臂长的均质化合物，在优化和表征交联应用方面提供了更高的精度。 含有 N-羟基琥珀酰亚胺（NHS） 酯的同型双功能交联剂通常用于蛋白质结构的低分辨率 3-D 研究和蛋白质相互作用分析。 特点和优势： · 反应基：NHS 酯（两端） · 反应性：氨基（伯胺） · 在 pH 7-9 下，NHS 酯与 -NH2 基反应形成稳定的酰胺键 · 水溶性；与非聚乙二醇化的 Bs3（也可溶）和 DSS（不溶于水）进行比较 · 不可透过膜，允许细胞表面标记 · 通过柔性PEG间隔臂不可逆地交联蛋白质或肽 · 聚乙二醇间隔臂有助于保持偶联物溶解度 · 有确定结构和分子量的纯化合物，确保可重复的蛋白质修饰效果 · PEG间隔臂提供独特的优势，包括增加稳定性、降低聚集倾向和降低免疫原性 · 非常适合小分子或肽结合 Bis-PEG5-NHS ester is a PEG derivative containing two NHS ester groups. The hydrophilic PEG spacer increases solubility in aqueous media. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. Features and Benefits · Reactive groups: NHS ester (both ends) · Reactive towards: amino groups (primary amines) · NHS esters react with—NH2 groups at pH 7-9, forming stable amide bonds · Water-soluble; compare to non-pegylated BS3 (also soluble) and DSS (water-insoluble) · Membrane-impermeable, allowing for cell surface labeling · Irreversibly crosslink proteins or peptides by flexible PEG spacer arms · Polyethylene glycol spacer arms help maintain conjugate solubility · Pure compound with defined structure and molecular weight, ensuring reproducible protein-modification effects · PEG spacer provides unique advantages, including increased stability, reduced tendency toward aggregation and reduced immunogenicity · Ideal for small molecule or peptide conjugations
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Bis-PEG5-NHS ester
CAS number：756526-03-1 molecular formula：C22H32N2O13
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Specs
| Chinese alias | 双-五聚乙二醇-琥珀酰亚胺酯 | 双-N-琥珀酰亚胺基-（五乙二醇）酯 | 双琥珀酰亚胺酯活化的PEG化合物 | 4,7,10,13,16-五氧杂十九烷二酸双(N-琥珀酰亚胺基)酯 | 双(2,5-二氧代吡咯烷-1-基) 4,7,10,13,16-五氧杂十九烷-1,19-二酸酯 | ||
| English alias | Bis-dPEG(R)5-NHS ester | PEG5 BIS-NHS ESTER | AKOS027250858 | GS-6157 | BP-20429 | (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[3-(2,5-dioxopyrrolidin-1-yl)oxy-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate | bis(2,5-dioxopyrrolidin-1-yl) 4,7,10,13,16-p | ||
| CAS number | 756526-03-1 | molecular formula | C22H32N2O13 |
| molecular weight | 532.50 g/mol | Exact mass | ≥98% |
| PSA | 174.000 Ų | logp | -2.600 |
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756526-03-1 | Bis(NHS)PEG5.pdf
