Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
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Recombinant Human Frizzled-4 Protein
CAS number：unknown molecular formula：
overview
compound introduction
Specs
| Chinese alias | 卷曲同源物4(FZD4)重组蛋白 | ||
| English alias | Fz-4 | FzE4 | hFz4 | CD344 | CD344 antigen | EVR1 | exudative vitreoretinopathy 1 | FEVR | frizzled (Drosophila) homolog 4 | frizzled homolog 4 (Drosophila) | Frizzled4 | Frizzled-4 | Fz-4 | FZD4 | FZD4S | FzE4 | GPCR | hFz4 | MGC34390 | WNT receptor friz | ||
| CAS number | unknown | molecular formula | |
| molecular weight | - | Exact mass | 无动物源 |
| PSA | - | logp | - |
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