Calcipotriol monohydrate is a synthetic VitD3 analogue with a high affinity for the vitamin D receptor. In Vitro When NHEK cells are not stimulated with IL-17A or IL-22, Calcipotriol slightly enhances (0.2 nM) IL-8 mRNA expression or has no effect (2-20 nM). The addition of IL-17A and IL-22 markedly increased the mRNA expression of IL-8, confirming our previous study. This enhanced IL-8 mRNA expression is suppressed by Calcipotriol at 2, 20 and 40 nM in a dose dependent manner. Treatment of natural killer (NK) cells with drugs modulates their expression of NK cytotoxicity receptors or KIR. Human NK cells are pre-treated with 100, 10 or 1 ng/mL of 1,25(OH) 2 D 3 , Calcipotriol or FTY720 for 4 h. All three concentrations of 1,25(OH) 2 D 3 , Calcipotriol and FTY720 significantly up-regulate the expression of NKp30 on the surface of NK cells after 4 h incubation. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo One out of the 32 animals in each of the groups has died, except for the Diclofenac plus DFMO plus Calcipotriol group, where all animals survived. Survival is equally distributed between the groups. The weight gain is significantly smaller in the groups treated with Diclofenac plus Calcipotriol (p=0.018) and Diclofenac plus DFMO plus Calcipotriol (p=0.002) compare with placebo (linear regression model). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:vitamin D receptor
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
Calcipotriol monohydrate
CAS number：147657-22-5 molecular formula：C27H42O4
overview
compound introduction
Specs
| Chinese alias | 卡泊三醇一水合物 | ||
| English alias | TESTOLACTONE (USP IMPURITY) | Calcipotriol hydrate, >=98% (HPLC) | AKOS025312514 | (1S,3R,5Z,7E,22E,24S)-26,27-cyclo-9,10-secocholesta-5,7,10,22-tetraene-1,3,24-triol hydrate | 9,10-SECOCHOLA-5,7,10(19),22-TETRAENE-1,3,24-TRIOL, 24-CYCLOPROPYL-, (1.ALPHA. | ||
| CAS number | 147657-22-5 | molecular formula | C27H42O4 |
| molecular weight | 430.62 g/mol | Exact mass | ≥99% |
| PSA | 61.700 Ų | logp | - |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
No safety information yet
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 1 shareMSDS
147657-22-5 | CALCIPOTRIOL MONOHYDRATE.pdf
