•细胞焦亡是一种新的程序性细胞死亡方式,其特征为依赖于半胱天冬酶-1(caspase-1),并伴有大量促炎症因子的释放。细胞焦亡广泛参与感染性疾病、神经系统相关疾病和动脉粥样硬化性疾病等的发生发展,并发挥重要作用。最近研究表明细胞焦亡能够增强抗肿瘤免疫; •668种细胞焦亡相关化合物的独特集合,用于高通量筛选(HTS)和高内涵筛选(HCS); •某些化合物已被FDA批准; •结构多样,具有药用活性且可渗透细胞; •提供丰富的文档信息,包括化合物结构和生物活性信息; •验证NMR和HPLC以确保高纯度。 详细信息 配制:
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