CAS number：2378801-85-3 molecular formula：C45H45BrN6O10S
PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC based on Cereblon ligand, which potently and selectively induces the degradation of Bcl-2 ( IC 50 , 4.94 μM; DC 50 , 3.0 μM) and Mcl-1 ( IC 50 , 11.81 μM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1 Form:Solid IC50& Target:Bcl-2 3 μM (DC 50 ) Bcl-2 4.94 μM (IC 50 ) Mcl-1 11.81 μM (IC 50 )
| Chinese alias | PROTAC Bcl2降解剂-1 | ||
| English alias | - | ||
| CAS number | 2378801-85-3 | molecular formula | C45H45BrN6O10S |
| molecular weight | 941.84 g/mol | Exact mass | ≥98% |
| PSA | 235.000 Ų | logp | 4.300 |
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