BSJ-04-132 is a PROTAC connected by ligands for Cereblon and CDK . BSJ-04-132 is a potent and selective Ribociclib-based CDK4 degrader ( PROTAC ), with IC 50 s of 50.6 nM and 30 nM for CDK4/D1 and CDK6/D1, respectively. BSJ-04-132 does not induce CDK6 and IKZF1/3 degradation. BSJ-04-132 has anti-cancer activity In Vitro BSJ-04-132 (0.1-5 μM; for 4 hours) only resultes in degradation of CDK4 in WT cells, not CDK6 and IKZF1/3. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: Wildtype (WT) or Crbn -/- Jurkat cells Concentration: 0.1, 0.5, 1, 5 μM Incubation Time: For 4 hours Result: Only resulted in degradation of CDK4 in WT cells, not CDK6 and IKZF1/3. Form:Solid IC50& Target:CDK4/D1 50.6 nM (IC 50 ) CDK6/D1 30 nM (IC 50 )
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BSJ-04-132
CAS number：2349356-39-2 molecular formula：C42H49N11O7
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 2349356-39-2 | molecular formula | C42H49N11O7 |
| molecular weight | 819.91 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
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