CAS number：755753-89-0 molecular formula：C24H16F2N4
Org 48762-0 is a selective p38α and β kinase inhibitor (EC50 = 0.1 μM for p38α). Selective for p38α/β over a panel of 48 other human kinases. Inhibits LPS-induced TNFα release from PBMCs. Also inhibits cytokine release in an LPS-induced endotoxemia model in mice. Orally bioavailable.
| Chinese alias | 4,6-双(4-氟苯基)-2-甲基-5-(4-吡啶基)-2H-吡唑并[3,4-b]吡啶 | ||
| English alias | Org 48762-0 | SCHEMBL1386962 | 4,6-Bis(4-fluorophenyl)-2-methyl-5-(pyridin-4-yl)-2H-pyrazolo[3,4-b]pyridine | HY-114221 | 4,6-bis(4-fluorophenyl)-2-methyl-5-pyridin-4-ylpyrazolo[3,4-b]pyridine | 4,6-Bis(4-fluorophenyl)-2-methyl-5-(4-pyridyl)-2H-pyrazolo(3 | ||
| CAS number | 755753-89-0 | molecular formula | C24H16F2N4 |
| molecular weight | 398.41 g/mol | Exact mass | ≥98% |
| PSA | 43.600 Ų | logp | 4.900 |
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