compound introduction
CTA 056 是一种 ITK（IL-2 诱导型 T 细胞激酶）抑制剂，IC50 为 0.1 μM。 CTA 056 选择性地靶向恶性 T 细胞并调节肿瘤细胞。 CTA 056 诱导细胞凋亡，是治疗 T 细胞白血病和淋巴瘤的潜在治疗剂。 Interleukin-2-inducible T-cell kinase (ITK) inhibitor (IC50 values are 0.1, 0.4 and 5 μM for ITK, BTK and ETK, respectively). Inhibits growth of cancer cells expressing ITK, including MOLT-4 and Jurkat cells in vitro. Induces apoptosis in Jurkat cells. Inhibits MOLT-4 xenograft tumor growth in mice. Application： CTA 056 is an ITK (IL-2 induced T cell kinase) inhibitor with an IC50 of 0.1 μM. CTA 056 selectively targets malignant T cells and regulates tumor cells. CTA 056 induces apoptosis and is a potential therapeutic agent for the treatment of T-cell leukemia and lymphoma.
