CAS number：2234272-10-5 molecular formula：C16H13N5
Explanation： AP C5 is a potent and selective protein kinase G type II (PKG2) inhibitor (pIC50 = 7.2). Displays >20-fold selectivity for PKG2 over PKG1 and PKA (pIC50 values are 4.6 and 4.8 for PKG1 and PKA, respectively). Blocks 8-pCPT-cGMP-dependent VASP phosphorylation in intestinal organoids. Also attenuates toxin-stimulated anion secretory responses in mouse intestinal tissue.
| Chinese alias | 4-[4-(1H-咪唑-1-基)苯基] -N-2-丙炔-1-基-2-嘧啶胺 | ||
| English alias | 4-[4-(1H-Imidazol-1-yl)phenyl]-N-2-propyn-1-yl-2-pyrimidinamine | ||
| CAS number | 2234272-10-5 | molecular formula | C16H13N5 |
| molecular weight | 275.31 g/mol | Exact mass | ≥98%(HPLC) |
| PSA | - | logp | - |
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