Mps1-IN-2 is a potent, selective and ATP-competitive dual Mps1/Plk1 inhibitor, with an IC 50 and a K d of 145 nM and 12 nM for Mps1 and a K d of 61 nM for Plk1 . In Vitro Mps1-IN-2 is a potent, selective and ATP-competitive Mps1 kinase inhibitor, with an IC 50 and a K d of 145 nM and 12 nM. Mps1-IN-2 also shows high affinity for PLK1 and GAK with K d s of 61 and 140 nM, respectively, but shows little or no inhibition on other 352 member kinases. Mps1-IN-2 can induces bypass of a checkpoint-mediated mitotic arrest in U2OS cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Mps1 12 nM (Kd) GAK 140 nM (Kd) PLK1 61 nM (Kd) PLK3 1600 nM (Kd) PLK4 3100 nM (Kd) STK33 5000 nM (Kd)
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Mps1-IN-2
CAS number：1228817-38-6 molecular formula：C26H36N6O3
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 1228817-38-6 | molecular formula | C26H36N6O3 |
| molecular weight | 480.60 g/mol | Exact mass | ≥98% |
| PSA | 94.100 Ų | logp | 3.200 |
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