WDR5-IN-1 is a potent and selective WD repeat domain 5 (WDR5) inhibitor, with a K d of In Vitro WDR5-IN-1 (1 µM; 48 hours) shows an apparent decrease in G2M phase cells. WDR5-IN-1 (0.01-3 µM; 24-48 hours) increases p53 and p21 protein levels. WDR5-IN-1 shows anti-proliferative activity in MYC-driven cancers (CHP-134, Ramos, Raji, Daudi, SW620, SW480 cells), with GI50s ranging from 0.26-3.2 µM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Cycle AnalysisCell Line: MV4:11 cells Concentration: 1 µM Incubation Time: 48 hours Result: Showed an approximate 4 fold increased SubG1 cells. Western Blot AnalysisCell Line: MV4:11 cells Concentration: 0.01, 0.03, 0.1, 0.3, 1, 3 µM Incubation Time: 24, 48 hours Result: p53 and p21 protein levels started to increase from 8 h post treatment of compound 16 at 300 nM and continued to elevate up to 32 h. Form:Solid
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WDR5-IN-1
CAS number：2408842-51-1 molecular formula：C30H31FN4O3
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 2408842-51-1 | molecular formula | C30H31FN4O3 |
| molecular weight | 514.59 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
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