Protease-Activated Receptor-1, PAR-1 Agonist is a selective proteinase-activated receptor1 (PAR-1) agonist peptide. Protease-Activated Receptor-1, PAR-1 Agonist corresponds to PAR1 tethered ligand and which can selectively mimic theactions of thrombin via this receptor In Vitro Protease-Activated Receptor-1, PAR-1 Agonist induces activation of protein kinase C isoenzymes alpha and epsilon in human HT-29 colon carcinoma cells expressing PAR1 endogeneously. On the cellular level, Protease-Activated Receptor-1, PAR-1 Agonist and thrombin prompted HT-29 cell migration and matrix adhesion by a PKCepsilon-dependent mechanism as concluded because of the inhibition of PAR1-mediated effects by the PKC inhibitor bisindolylmaleimide I and the PKCepsilon translocation inhibitory peptide EAVSLKPT but not by the PKC inhibitor Gö 6976. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:PAR-1
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Protease-Activated Receptor-1, PAR-1 Agonist
CAS number：141136-85-8 molecular formula：C35H58N10O9
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| Chinese alias | 蛋白酶激活受体-1、PAR-1 激动剂 | ||
| English alias | - | ||
| CAS number | 141136-85-8 | molecular formula | C35H58N10O9 |
| molecular weight | 762.90 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
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