Vorinostat-d5 (SAHA-d5) is the deuterium labeled Vorinostat. Vorinostat (SAHA) is a potent and orally active pan-inhibitor of HDAC1 , HDAC2 and HDAC3 (Class I) , HDAC7 (Class II) and HDAC11 (Class IV) , with ID 50 values of 10 nM and 20 nM for HDAC1 and HDAC3 , respectively. Vorinostat induces cell apoptosis. Vorinostat is also an effective inhibitor of human papillomaviruse (HPV)-18 DNA amplification. In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid
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Vorinostat-d5
CAS number：1132749-48-4 molecular formula：C14H15D5N2O3
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| Chinese alias | 伏立诺他-d5 | ||
| English alias | - | ||
| CAS number | 1132749-48-4 | molecular formula | C14H15D5N2O3 |
| molecular weight | 269.35 g/mol | Exact mass | ≥99% |
| PSA | 78.400 Ų | logp | 1.900 |
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