KN-93 phosphate is a novel membrane-permeant synthetic inhibitor of purified neuronal CaMK-II , with K i of 370 nM. In Vitro After 2 days of KN-93 treatment, 95% of cells are arrested in G1. G1 arrest is reversible; 1 day after KN-93 release, a peak of cells had progressed into S and G2-M. KN-93 also blocks cell growth stimulated by basic fibroblast growth factor, platelet-derived growth factor-BB, and epidermal growth factor in NIH 3T3 fibroblasts. KN-93 inhibits the H + , K + -ATPase activity but strongly dissipates the proton gradient formed in the gastric membrane vesicles and reduces the volume of luminal space. KN-93 (0.5 μM) prevents increased LV developed pressure during action potential prolongation and early afterdepolarizations. Ca 2+ -independent CaM kinase activity is increased during early afterdepolarizations and this increase is prevented by KN-93. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:CaMK II
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KN-93 phosphate
CAS number：1913269-12-1(DMSO) molecular formula：C26H32ClN2O8PS
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| Chinese alias | KN-93磷酸盐 | ||
| English alias | - | ||
| CAS number | 1913269-12-1(DMSO) | molecular formula | C26H32ClN2O8PS |
| molecular weight | 599.03 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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