CAS number：835621-07-3 molecular formula：C21H16Cl2F4N4O3
Information Regorafenib (Stivarga, BAY 73-4506) Hydrochloride is a multi-target inhibitor forVEGFR1,Murine VEGFR2/3,PDGFRβ,Kit (c-Kit),RET (c-RET)andRaf-1with IC50 of 13 nM, 4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively. Targets RET (Cell-free assay); Raf-1 (Cell-free assay); Murine VEGFR2 (Cell-free assay); Kit (Cell-free assay); VEGFR1 (Cell-free assay) 34591,1.5 nM; 2.5 nM; 4.2 nM; 7 nM; 13 nM
| Chinese alias | - | ||
| English alias | 4-[4-({[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide--hydrogen chloride (1/1) | Regorafenib HCl | 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamide hydrochlorid | ||
| CAS number | 835621-07-3 | molecular formula | C21H16Cl2F4N4O3 |
| molecular weight | 519.28 g/mol | Exact mass | 10mM in DMSO |
| PSA | 92.400 Ų | logp | 4.763 |
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