亚油酰甘氨酸是亚油酰甘氨酸亚油酰乙醇酰胺的内源同系物。花生四烯酸甘氨酸是在哺乳动物皮肤，脊髓和大脑中产生的花生四烯酸和甘氨酸的结合物，它是anandamide（AEA）的结构对应物，据报道在整个动物实验中具有镇痛作用。它对中央大麻素（CB1）受体的亲和力较弱，对G蛋白偶联受体GPR-18的亲和力高，并且受脂肪酸酰胺水解酶（FAAH）活性的代谢调控。亚油酰基甘氨酸抑制含有FAAH的N18TG2细胞膜（IC | 50 |〜25 µM）中AEA的水解，其效力低于花生四烯酸甘氨酸（IC | 50 | = 7 µM Linoleoyl glycine is an endogenous homolog of linoleoyl ethanolamide, an arachidonyl glycine. Arachidonyl glycine, the conjugate of arachidonic acid and glycine produced in mammalian skin, spinal cord and brain, is a structural counterpart of anandamide (AEA) that is reported to have analgesic activities in whole animal experiments. It has poor affinity for the central cannabinoid (CB1) receptor, high-affinity for the G protein-coupled receptor GPR-18, and is metabolically regulated by fatty acid amide hydrolase (FAAH) activity. Linoleoyl glycine inhibits the hydrolysis of AEA in FAAH-containing N18TG2 cell membranes (IC|50|~ 25 μM), which is less potent than that of arachidonyl glycine (IC|50|= 7 μM). The biological significance of linoleoyl glycine has not yet been determined.
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
Linoleoyl glycine
CAS number：2764-03-6 molecular formula：C20H35NO3
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | 2-[[(9Z,12Z)-octadeca-9,12-dienoyl]amino]acetic acid | Glycine-linoleamide | SCHEMBL6681636 | NCGC00161201-06 | HMS1791I08 | IDI1_033916 | NCGC00161201-05 | J-016835 | linolyl glycine | HMS1361I08 | BRD-K76293260-001-02-6 | ((9Z,12Z)-Octadeca-9,12-dienoyl | ||
| CAS number | 2764-03-6 | molecular formula | C20H35NO3 |
| molecular weight | 337.5 g/mol | Exact mass | ≥97% |
| PSA | 66.400 Ų | logp | 5.900 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
No safety information yet
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
