Information Mizagliflozin (KWA 0711) Mizagliflozin (KWA 0711) is a novel, potent, selective sodium glucose co-transporter 1 (SGLT1) inhibitor with Ki of 27 nM for human SGLT1. The selectivity ratio (Ki value for human SGLT2/Ki value for human SGLT1) of mizagliflozin is 303. Mizagliflozin shows the potential use for the amelioration of chronic constipation. Targets human SGLT1 (Cell-free assay) 27 nM(Ki) In vitro Mizagliflozin\'s inhibitory activity against SGLTs is evaluated by an in vitro assay of cells transiently expressing SGLTs. Mizagliflozin potently inhibits human SGLT1 in a highly selective manner.. In vivo The oral administration of Mizagliflozin increased fecal wet weight in a dog model of loperamide-induced constipation and a rat model of low-fiber-diet-induced constipation.. Cell Research(from reference) Cell lines：COS-7 cells Concentrations：0-1 μM, 0-30 μM Incubation Time：1 h
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Mizagliflozin (KWA 0711)
CAS number：666843-10-3 molecular formula：C28H44N4O8
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| Chinese alias | 3-((3-(4-((5-异丙基-3-(((2S,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)-1H-吡唑-4-基)甲基)-3-甲基苯氧基)丙基)氨基)-2,2-二甲基丙酰胺 | ||
| English alias | HY-17638 | EX-A4127 | GSK-1614235 free baseDSP-3235 free base | KGA-3235 free base | Propanamide, 3-((3-(4-((3-(beta-D-glucopyranosyloxy)-5-(1-methylethyl)-1H-pyrazol-4-yl)methyl)-3-methylphenoxy)propyl)amino)-2,2-dimethyl- | Mizagliflozin [INN:WHO-DD] | | ||
| CAS number | 666843-10-3 | molecular formula | C28H44N4O8 |
| molecular weight | 564.67 g/mol | Exact mass | - |
| PSA | 192.000 Ų | logp | 1.500 |
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