compound introduction
产品介绍： HOIPIN-1 (JTP-0819958) 是线性泛素链组装复合物 (LUBAC) 的选择性抑制剂 (IC 50 = 2.8 μM)，可在体外抑制由 LUBAC 介导的 NF-kB 激活 Product description： HOIPIN-1 (JTP-0819958) is a selective inhibitor of linear ubiquitin chain assembly complex (LUBAC) (IC 50=2.8) μ M) It can inhibit NF-kB activation mediated by LUBAC in vitro Information ： HOIPIN-1 (JTP-0819958, HOIP inhibitor-1) is a linear ubiquitin chain assembly complex (LUBAC) inhibitor with IC50 of 2.8 μM. HOIPIN-1 specifically generates Met1-linked linear ubiquitin chains through the ubiquitin ligase activity in HOIP, and activates the NF-kB pathway.
