compound introduction
Tofacitinib(CP-690550)是高效JAK3抑制剂，IC50为1 nM，比对JAK2和JAK1的抑制性高20倍和100倍。 Tofacitinib(CP-690550) is a novel inhibitor of JAK3 with IC50 of 1 nM, 20- to 100-fold less potent against JAK2 and JAK1.
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(3R,4S)-Tofacitinib
CAS number：1092578-46-5 molecular formula：C16H20N6O
overview
Specs
| Chinese alias | (3R,4S)-托法替尼 | ||
| English alias | UNII-B64WR5WNB7 | D86134 | (3R,4S)-4-Methyl-3-(methyl-7H-pyrrolo(2,3-d)pyrimidin-4-ylamino)-beta-oxo-1-piperidinepropanenitrile | 3-((3R,4S)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile | 1-PIPERIDINEPROPANE | ||
| CAS number | 1092578-46-5 | molecular formula | C16H20N6O |
| molecular weight | 312.37 g/mol | Exact mass | ≥98% |
| PSA | 88.900 Ų | logp | 1.500 |
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