compound introduction
PDGFR酪氨酸激酶抑制剂II是细胞可渗透的异硫脲化合物，可特异性，快速和可逆地扰乱MreB功能，而不会影响真核肌动蛋白的聚合反应。据报道，PDGFR酪氨酸激酶抑制剂II可影响新月形杆菌的生长和形态，将杆状大肠杆菌转化为圆形细胞，并在不影响DNA复制的情况下阻断DNA分离。PDGFR酪氨酸激酶抑制剂II被怀疑与MreB的核苷酸结合袋相互作用，可用于MreB功能的时间分析。 PDGFR Tyrosine Kinase Inhibitor II is a cell-permeable isothiourea compound that specifically, rapidly and reversibly perturbs MreB function without affecting eukaryotic actin polymerization. PDGFR Tyrosine Kinase Inhibitor II is reported to affect the growth and morphology of Caulobacter crescentus, convert rod-shaped E. coli to round cells, and block DNA segregation without affecting DNA replication. PDGFR Tyrosine Kinase Inhibitor II is suspected to interact with MreB's nucleotide binding pocket and is useful for the temporal analysis of MreB function.
